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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Gambogic Acid, TNF-related apoptosis inducing ligand
Phytochemical Name Gambogic Acid (PubChem CID: 9852185 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 881
Ref_1
Pair Name Gambogic Acid, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BCL-xL hsa598
Down-regulation Expression BID hsa637
Down-regulation Expression BIRC5 hsa332
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP7 hsa840
Up-regulation Cleavage CASP8 hsa841
Down-regulation Cleavage PARP1 hsa142
Up-regulation Expression XIAP hsa331
In Vitro Model MCF-7 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0031
MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
Result These findings may open a new window in the treatment of breast cancer using TRAIL in combination with GA.
03. Reference
No. Title Href
1 Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings. Food Chem Toxicol. 2018 Sep;119:334-341. doi: 10.1016/j.fct.2018.02.037. Click
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